Hello mailing-list!
Actually I'm about to create a model of a tyrosine-receptor-kinase
(named FLT3 - pdb-code: 1rjb). However, the problem is that I have to
model a mutation of this receptor. A point mutation would be easy to
handle, but in my case the receptor contains a so called "internal
tandem duplication" which is an insert whose length is ~13-30 amino
acids at a specific point. The inserted sequence is out of the same
exon, so the native structure of this sequence within the wild type is
known.
Example (just to illustrate!):
wild type:
XXXXXXXXXXYYYYYYYYYY
mutation
XXXXXXXXXXaaaaaaaaaaaaaaaYYYYYYYYYY (a = itd)
Any suggestions how to model such a ITD-sequence into a wild type
receptor?
Thanks so far.
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