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I was looking for help on how to use data from 240S Illumina
chips for linkage. I ran a family on these chips which genotype 240,000 SNPs across
the genome. Unfortunately none of the linkage programs that I have looked at are
able to handle this amount of data. Even SNPlink which is designed to cut down
the large numbers of SNPs does not work with such a large dataset. One approach
that I was thinking of following is to match the SNPs on Illumina’s
linkage panel V to the SNPs that I have generated using the 240S SNP chip. Problem
is that not all of the linkage panel V SNPs are on the 240S Illumina SNP chip,
so I may have to take nearby SNPs. My questions are as follows:
(1)
Has anyone any experience with using 240S or 550K
Illumina SNP chips for linkage studies?
(2)
Does anyone have a list of SNPs on the 240S SNP chip
that they know work for linkage?
Many thanks in advance,
Best,
Bryan
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