WARNING: This server is unstable and will be retired in the next days.
If you want to keep this forum available, please request immediately a migration
on the Nabble Support forum.
Forums that don't receive any migration request will be deleted forever.
I'm looking for advice on planning the development of a prognostic model. Does anyone have a reference giving advice on the types of studies required for the various stages of development? I have the Pepe book but this is aimed more at diagnostic tests and it's hard to translate to what is needed for a prognostic model.
We have a relatively small case-control study on which the initial exploratory work has been carried out on. We would like to take four models forward as potentially promising but I am proposing a follow-on study (also retrospective case-control) to use ROC curves to identify optimal cutpoints for risk stratification and get better estimates for the weights of each factor in the model. Is it sufficient at this stage to for example use 10 cases per factor in the model and match with the same number of control subjects? Or could we calculate sample size based on achieving minimum predictive values at this point? Would we determine the best model at this stage and then proceed to a prospective validation study or is there another step first?
Many thanks in advance for any suggestions,
You may leave the list at any time by sending the command