Request For Help in my project

[jitesh dundas]

Dear Sir/Madam,

I would like to invite you to become my co-author for the following
paper.  I need someone with lab facilities to carry out the experiments
needed for this project.

I need an expert like you help me get positive results in the project
(details below):-

Abstract:-
--------------

The human cells are known to be very dynamic and continuously changing
with time. They also adapt and change due to the evolution and other
external/internal factors.

Each cell has the capability to resist external pathogens and other
objects that may be unfavorable for it. Thus, there are mechanisms in
place for doing this:-
Cells have numerous defenses against invading pathogens, including
production of interferon, presentation on MHCI/II, and degradation of
incoming RNAs by  dsRNA-dependent protein kinase R (PKR).

I am working on a formula that can predict the resistance of a cell
toward such pathogens in future (e.g. 45 days ,365 days , etc).
Suppose a cell has 70% capacity to resist a pathogen right now. What
will be the capacity of the cell to resist this pathogen after 365
days.

There are 2 things here to note. Firstly, we need to find the capacity
of the cell to resist at this point (Some experts might call this
immunity, but I am being specific to a specific disease i.e.
Cancer/HIV Aids here). We cannot consider this formula to be measuring
just the amount of interferon ,p53 or other cancer related parameters
as they alone do not lead to cancer.

Secondly, we need to find the future capability of this cell to resist
such pathogens. There are several parameters in play here.

Also, we need to understand these things:-
a) The cells are continuously changing due to evolution and have a
life till apoptosis.
 b) The pathogens or external agents are also dynamic and evolving
with time .For diseases TB and Swine flu, the virus is changing its
shape every 6 months
c) The pathogens may combine and form a very strong hybrid strand of
pathogens, against which our cells may be weak.  For e.g.) It is
elementary that the current swine flu will form a deadly strand with
HIV AIDS virus and become very deadly.
 d) Both these complex systems are evolving with time and with the
life cycle and reproduction capabilities, we need to find the exact
capabilities of each of the above conditions.

What I want in a formula is the capacity (consider the unit for this
measure as immunity units/day) which will allow me to make a
probabilistically accurate measure of the resistance of the cell
against an invading pathogen in future.

For now, we consider known pathogens, but I intend to extend this to
unknown strands as well.


References:-
----------------------
Lodish et al, Introduction to Cell & Molecular Biology

Takaoka A, Hayakawa S, Yanai H, et al. (2003). "Integration of
interferon-alpha/beta signalling to p53 responses in tumour
suppression and antiviral defence". Nature 424 (6948): 516–23.
doi:10.1038/nature01850. PMID 12872134.
http://www.nature.com/nature/journal/v424/n6948/pdf/nature01850.pdf.

http://www.cehs.siu.edu/fix/medmicro/mhc.htm

Weiss RA. How does HIV cause AIDS? Science. 1993 May
8;260(5112):1273-9.URL: http://www.ncbi.nlm.nih.gov/pubmed/8493571

D J Alexander. Ecological aspects of influenza A viruses in animals
and their relationship to human influenza: a review. J R Soc Med. 1982
October; 75(10): 799–811.Online:
http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1438138&blobtype=pdf
----------------------

May I request your feedback on the above topic. I have developed the
initial version of this formula which I expect to present in 1-2
months. Still, think it will be best to take the opinion of experts
like you on this topic.

I look forward to hearing from you soon. I understand that you are
very busy and I thank you for reading this message.

Please let me know if you need anything else from my side. I eagerly
await your reply

Thanks & Regards,
Jitesh Dundas

jitesh@...
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