SMTP transport with e-mail address in DataBase

Hi,

I would like to send e-mail trow smtp transport. But the e-mail address is in data base and it depend of data in the payload. Is it possible to take data in the DataBase with the mule ant put it in the e-mail address of the smtp transport ?
If not I can put it on the object in the payload. But how can I extract it for the smtp transport?

Youkoun