US/VA Computational Biology Postdoc at SRI

[Frederic Vigneault]

*Job* *Title*: Postdoctoral Fellow - Computational Biology
*Location*: VA - Shenandoah Valley
*Job* *ID*: 100025 </>
*SRI International - CADRE*
SRI International (http://www.sri.com) is one of the world's leading
independent research and technology development organizations. The nonprofit
research institute performs client-sponsored research and development for
government agencies, commercial businesses and private foundations, forms
strategic partnerships, licenses its technologies, and creates spin-off
companies.

The new SRI Center for Advanced Drug Research
(CADRE<http://www.sri.com/biosciences/cadre/>)
at Shenandoah Valley in Harrisonburg, VA, in collaboration with Pathway
Logic group at SRI Menlo Park, is developing a computational modeling group
that will collaborate with experimental researchers to enable new insights
emerging from a close integration of experiment and modeling. One position
is currently available, but other positions are expected to open in the
coming years.

*Job Description*
A ground floor opportunity for researchers interested in new directions for
systems and computational biology is currently open. The task includes
curation and computational validation of models of metabolic and signal
transduction pathways. The work will involve deriving mechanisms/reactions
from relevant published literature and reports of experimental results to
populate knowledge bases of metabolic and/or signaling reactions.

The Pathway Logic system (http://pl.csl.sri.com/) will be used to analyze
and validate the resulting growing network of reactions. This system is
based on a novel approach to model biological pathways using logic-based
methods developed to model concurrent processes. Networks can be navigated
and queried interactively to gain an understanding of the interconnections
and possible outcomes. Curators will work with experimental biologists to
fill in gaps in pathways of interest. Results of testing hypotheses
generated by the computational validation and analysis will be used to
refine the models.

Training in the use of Pathway Logic will be provided.

*Requirements*
Candidates should have Ph.D. or equivalent experience in a biology oriented
discipline. In particular, they should have substantial understanding of
cellular biology and the experimental methods used in the study of cellular
processes such as metabolics or cell signaling. The candidate should be
comfortable using computers, and have an interest in using computational
methods to develop models of biological processes. Experience with
programming, formal methods, computational modeling or bioinformatics tools
is desirable, but not required. Knowledge about immune systems is
particularly welcome.

Research at SRI is highly interactive and collaborative, and we expect
applicants to contribute to our intellectually open culture. There are
extensive opportunities for collaboration within SRI, federal agencies and
with universities. Opportunities exist for holding adjunct appointments at a
local university. Successful candidates will be expected to obtain national
and international research funding, publish their results in refereed
journals, and mentor junior researchers.

For more information, please feel welcome to contact me:
frederic.vigneault@...
540.568.5746
Bioscience Division
SRI Shenandoah Valley
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